Translating Neuroconcepts into Neurotherapies

Miletic Research Group
Experimental Neuro-oncology & Neuropathology

Selected Publications

Tumor versus Stromal Cells in Culture-Survival of the Fittest? Talasila KM, Brekka N, Mangseth K, Stieber D, Evensen L, Rosland GV, Torsvik A, Wagner M, Niclou SP, Mahesparan R, Vintermyr OK, Bjerkvig R, Nigro JM, Miletic H. PLoS One. 2013 Dec 2;8(12):e81183. doi. [PubMed - in process]

Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF. Podergajs N, Brekka N, Radlwimmer B, Herold-Mende C, Talasila KM, Tiemann K, Rajcevic U, Lah TT, Bjerkvig R, Miletic H. Radiol Oncol. 2013 Oct 8;47(4):330-7

A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Klink B, Miletic H, Stieber D, Huszthy PC, Valenzuela JA, Balss J, Wang J, Schubert M, Sakariassen PØ, Sundstrøm T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou SP, Schröck E, Bjerkvig R, Nigro JM. PLoS One. 2013;8(3). Epub 2013 Mar 19.

Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI.
Viel T, Talasila KM, Monfared P, Wang J, Jikeli JF, Waerzeggers Y, Neumaier B, Backes H, Brekka N, Thorsen F, Stieber D, Niclou SP, Winkeler A, Tavitian B, Hoehn M, Bjerkvig R, Miletic H, Jacobs AH. J Nucl Med. 2012 Jul;53(7):1135-45. Epub 2012 Jun 11.

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.
Talasila KM, Soentgerath A, Euskirchen P, Rosland GV, Wang J, Huszthy PC, Prestegarden L, Skaftnesmo KO, Sakariassen PO, Eskilsson E, Stieber D, Keunen O, Brekka N, Moen I, Nigro JM, Vintermyr OK, Lund-Johansen M, Niclou S, Mørk SJ, Enger PO, Bjerkvig R, Miletic H.Acta Neuropathol. 2013 May;125(5):683-98. Epub 2013 Feb 22.

NUMB does not impair growth and differentiation status of experimental gliomas.
Euskirchen P, Skaftnesmo KO, Huszthy PC, Brekkå N, Bjerkvig R, Jacobs AH, Miletic H. Exp Cell Res. 2011 Dec 10;317(20):2864-73. Epub 2011 Sep 12.

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.
Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, Thorsen F, Taxt T, Bartos M, Jirik R, Miletic H, Wang J, Stieber D, Stuhr L, Moen I, Rygh CB, Bjerkvig R, Niclou SP. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3749-54. Epub 2011 Feb 14.

A reproducible brain tumour model established from human glioblastoma biopsies.
Wang J, Miletic H, Sakariassen PØ, Huszthy PC, Jacobsen H, Brekkå N, Li X, Zhao P, Mørk S, Chekenya M, Bjerkvig R, Enger PØ. BMC Cancer. 2009 Dec 29;9:465.

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment. Huszthy PC, Immervoll H, Wang J, Goplen D, Miletic H, Eide GE, Bjerkvig R. Gene Ther. 2010 Feb;17(2):202-16. Epub 2009 Oct 15.

Cancer stem cells and angiogenesis. Bjerkvig R, Johansson M, Miletic H, Niclou SP. Semin Cancer Biol. 2009 Oct;19(5):279-84. Epub 2009 Oct 7. Review.

iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Rajcevic U, Petersen K, Knol JC, Loos M, Bougnaud S, Klychnikov O, Li KW, Pham TV, Wang J, Miletic H, Peng Z, Bjerkvig R, Jimenez CR, Niclou SP. Mol Cell Proteomics. 2009 Nov;8(11):2595-612. Epub 2009 Aug 12.

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. Huszthy PC, Giroglou T, Tsinkalovsky O, Euskirchen P, Skaftnesmo KO, Bjerkvig R, von Laer D, Miletic H. PLoS One. 2009 Jul 20;4(7):e6314.

Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Miletic H, Niclou SP, Johansson M, Bjerkvig R. Expert Opin Ther Targets. 2009 Apr;13(4):455-68. Review.

Multimodal imaging of neural progenitor cell fate in rodents. Waerzeggers Y, Klein M, Miletic H, Himmelreich U, Li H, Monfared P, Herrlinger U, Hoehn M, Coenen HH, Weller M, Winkeler A, Jacobs AH. Mol Imaging. 2008 Mar-Apr;7(2):77-91.

Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Huszthy PC, Goplen D, Thorsen F, Immervoll H, Wang J, Gutermann A, Miletic H, Bjerkvig R. Clin Cancer Res. 2008 Mar 1;14(5):1571-80.

Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma. Miletic H, Fischer YH, Giroglou T, Rueger MA, Winkeler A, Li H, Himmelreich U, Stenzel W, Jacobs AH, von Laer D. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6761-8.

A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells. Fischer YH, Miletic H, Giroglou T, Litwak S, Stenzel W, Neumann H, von Laer D. J Gene Med. 2007 May;9(5):335-44.

Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene. Miletic H, Fischer Y, Litwak S, Giroglou T, Waerzeggers Y, Winkeler A, Li H, Himmelreich U, Lange C, Stenzel W, Deckert M, Neumann H, Jacobs AH, von Laer D. Mol Ther. 2007 Jul;15(7):1373-81. Epub 2007 Apr 24.

Variability in infectivity of primary cell cultures of human brain tumors with HSV-1 amplicon vectors. Rueger MA, Winkeler A, Miletic H, Kaestle C, Richter R, Schneider G, Hilker R, Heneka MT, Ernestus RI, Hampl JA, Fraefel C, Jacobs AH. Gene Ther. 2005 Apr;12(7):588-96.

Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins. Miletic H, Fischer YH, Neumann H, Hans V, Stenzel W, Giroglou T, Hermann M, Deckert M, Von Laer D. Hum Gene Ther. 2004 Nov;15(11):1091-100.

Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Kracht LW, Miletic H, Busch S, Jacobs AH, Voges J, Hoevels M, Klein JC, Herholz K, Heiss WD. Clin Cancer Res. 2004 Nov 1;10(21):7163-70.

Recombinant expression of lymphocytic choriomeningitis virus strain WE glycoproteins: a single amino acid makes the difference. Beyer WR, Miletic H, Ostertag W, von Laer D. J Virol. 2001 Jan;75(2):1061-4.

Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus. Miletic H, Bruns M, Tsiakas K, Vogt B, Rezai R, Baum C, Kühlke K, Cosset FL, Ostertag W, Lother H, von Laer D. J Virol. 1999 Jul;73(7):6114-6.

All publications

But the power of science lies in open publication, which, with the rise of the Internet, is no longer constrained by the price of paper.

Michael Shermer